High-Quality Semisolid: Manufacturing at Adragos Leipzig

Semisolid, or semi-solid dosage form, is a topical or transdermal product with a consistency between a liquid and a solid. They include creams, ointments, gels, and pastes. Systems designed to deliver active pharmaceutical ingredients (APIs) to or through the skin in a controlled manner. Because their properties can be tailored for specific spreadability, occlusivity, residence time, and API release profiles, semi-solids are foundational in dermatology, wound care, musculoskeletal therapy, and cosmetic/dermocosmetic applications.

Key Advantages For Pharmaceutical Partners

• Tailored Drug Delivery: From rapid dermal penetration (e.g., gels) to prolonged occlusive contact (e.g., ointments).
• Patient-Centric Performance: Optimized texture, feel, and usability to encourage adherence.
• Scalable Manufacturing: GMP-compliant processes for both prescription (Rx) and over-the-counter (OTC) product pipelines.
• Packaging Solutions: A range of choices, such as tubes, that protect product quality and improve handling.

End-to-End Semisolid Manufacturing at Adragos Leipzig

Adragos Leipzig (Germany) is a center of excellence for semi-solids within Adragos Pharma’s network, working alongside our Halden (Norway) site. We support the product lifecycle from technology transfer through to commercial manufacturing and packaging, with rigorous testing and quality systems aligned with global regulatory expectations (e.g., EMA, FDA, ICH).

What You Can Expect When Partnering With Us

• Commercial Manufacturing: Services include process validation, scale-up, and routine commercial supply.
• Robust Process Control: We ensure consistent product performance through strict control of critical process parameters like viscosity, pH, and microstructure.
• Manufacturing Excellence: Processes include controlled heating/cooling, homogenization, deaeration, and precise in-process controls to ensure product uniformity and stability.
• Packaging Expertise: We provide compatibility screening and fill-finish processes designed to protect product integrity, with extensive experience in formats such as aluminum and plastic tubes.
• Quality and Compliance: Comprehensive testing and documentation are supported by robust GMP quality systems for global submissions.
• Technology Transfer: We conduct structured technology transfers to our site for commercial-scale manufacturing, as well as across network sites (Leipzig, Halden), to de-risk timelines.

Our Semisolid Portfolio: Creams, Ointments, Gels, and Healing Pastes

We manufacture high-quality semi-solids with performance characteristics designed to meet your target product profile. Semi-solids are versatile, patient-friendly dosage forms that demand rigorous manufacturing control. At Adragos Leipzig, we provide end-to-end expertise in creams, ointments, gels, and healing pastes, delivering spreadability, occlusivity, stability, and API release profiles aligned with your clinical and commercial goals.

Choosing the right manufacturing partner is a critical step to secure your product’s future. At Adragos Leipzig, we understand that a successful technology transfer and a secure, compliant supply chain are non-negotiable. Our team ensures your semi-solid product is going to be manufactured at the highest quality standards. Contact us today to learn how our team can support your product’s success and help you meet market demands.

FAQs About Semisolids